Grzegorz Sienski

BioPharmaceuticals R&D Unit, AstraZeneca
Goeteborg, O, Sweden

Last Updated: 09/26/2026

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Found 18 publications

Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.

Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.

Journal: Nature communications
Published: December 17, 2024

Optimized prime editing of the Alzheimer's disease-associated APOE4 mutation.

Optimized prime editing of the Alzheimer's disease-associated APOE4 mutation.

Journal: Stem cell reports
Published: October 01, 2024

SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.

SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.

Journal: Nature communications
Published: August 28, 2024

Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles.

Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles.

Journal: Nature communications
Published: February 28, 2024

A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo.

A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo.

Journal: Nature communications
Published: October 03, 2022

TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.

TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.

Journal: Nature communications
Published: January 05, 2022

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing.

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing.

Journal: Nature communications
Published: September 03, 2021

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.

Journal: Nature structural & molecular biology
Published: June 17, 2021

Author Correction: Universal toxin-based selection for precise genome engineering in human cells.

Author Correction: Universal toxin-based selection for precise genome engineering in human cells.

Journal: Nature communications
Published: May 11, 2021

Universal toxin-based selection for precise genome engineering in human cells.

Universal toxin-based selection for precise genome engineering in human cells.

Journal: Nature communications
Published: April 21, 2020

PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4.

PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4.

Journal: Cell reports
Published: February 27, 2020

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.

Journal: Science translational medicine
Published: September 10, 2019
Showing 1-12 of 18

Last Updated: 09/26/2026