Guangcan Xu

State Key Laboratory Of Discovery And Utilization Of Functional Components In Traditional Chinese Medicine
Guiyang, 550000, China

Last Updated: 09/26/2026

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Found 16 publications

Enantioselective Construction of Spirocyclohexadienones Via NHC-Catalyzed Formal [5 + 1] Annulation Reaction of Dienals.

Enantioselective Construction of Spirocyclohexadienones Via NHC-Catalyzed Formal [5 + 1] Annulation Reaction of Dienals.

Journal: Organic letters

Published: July 27, 2026

Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.

Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.

Journal: Bioorganic chemistry

Published: February 26, 2026

Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Journal: Molecular diversity

Published: February 14, 2026

Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.

Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.

Journal: Journal of medicinal chemistry

Published: February 03, 2026

A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.

A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.

Journal: Medical oncology (Northwood, London, England)

Published: September 28, 2025

Novel trifluoromethylquinoline derivatives as potent tubulin polymerization inhibitors with antitumor activity.

Novel trifluoromethylquinoline derivatives as potent tubulin polymerization inhibitors with antitumor activity.

Journal: Bioorganic & medicinal chemistry

Published: August 07, 2025

Correction: Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1.

Correction: Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1.

Journal: Molecular diversity

Published: April 29, 2025

Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents.

Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents.

Journal: Molecular diversity

Published: April 01, 2025

Discovery of novel quinazoline derivatives containing trifluoromethyl against cell proliferation by targeting werner helicase.

Discovery of novel quinazoline derivatives containing trifluoromethyl against cell proliferation by targeting werner helicase.

Journal: Molecular diversity

Published: January 22, 2025

Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity.

Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity.

Journal: European journal of medicinal chemistry

Published: October 22, 2024

Design, Synthesis, and Biological Evaluation of Novel Trifluoromethylated Dipeptide Mimetics of Matijin-Su as Potent Anti-HBV Agents.

Design, Synthesis, and Biological Evaluation of Novel Trifluoromethylated Dipeptide Mimetics of Matijin-Su as Potent Anti-HBV Agents.

Journal: Chemistry & biodiversity

Published: August 22, 2024

Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1.

Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1.

Journal: Molecular diversity

Published: June 12, 2024

Showing 1-12 of 16

Last Updated: 09/26/2026