Guangyuan Liu

Hubei Key Laboratory Of Natural Medicinal Chemistry And Resource Evaluation, No. 13 Hangkong Road
Wuhan, 430030, China

Last Updated: 09/26/2026

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Found 10 publications

Discovery of novel indole-chalcone derivatives as potent hexokinase 2 inhibitors for triple negative breast cancer therapy.

Discovery of novel indole-chalcone derivatives as potent hexokinase 2 inhibitors for triple negative breast cancer therapy.

Journal: Bioorganic chemistry

Published: June 19, 2026

Design, synthesis, and evaluation of indole-pyridine chalcone derivatives as novel HK2 inhibitors to modulate macrophage glycolysis and inflammation for IBD treatment.

Design, synthesis, and evaluation of indole-pyridine chalcone derivatives as novel HK2 inhibitors to modulate macrophage glycolysis and inflammation for IBD treatment.

Journal: European journal of medicinal chemistry

Published: March 06, 2026

Base-catalyzed regio- and stereoselective addition of isatins to trifluoromethylated alkynes for preparation of N-alkenylisatins.

Base-catalyzed regio- and stereoselective addition of isatins to trifluoromethylated alkynes for preparation of N-alkenylisatins.

Journal: Organic & biomolecular chemistry

Published: November 04, 2025

Recent advances in antitumor indole-chalcone derivatives: a mini review.

Recent advances in antitumor indole-chalcone derivatives: a mini review.

Journal: European journal of pharmacology

Published: September 08, 2025

Base-Catalyzed Chemo-, Regio- and Stereoselective Addition of Quinazolinones to Trifluoromethylated Internal Alkynes for Access to N3-Vinylquinazolinones.

Base-Catalyzed Chemo-, Regio- and Stereoselective Addition of Quinazolinones to Trifluoromethylated Internal Alkynes for Access to N3-Vinylquinazolinones.

Journal: Organic letters

Published: May 31, 2025

Discovery and validation of indole nitroolefins as novel covalent GPX4 inhibitors for inducing ferroptosis in urological cancers.

Discovery and validation of indole nitroolefins as novel covalent GPX4 inhibitors for inducing ferroptosis in urological cancers.

Journal: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Published: March 28, 2025

Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2.

Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2.

Journal: European journal of medicinal chemistry

Published: August 28, 2024

Site-Selective Synthesis of Antitumor C5-Aminated Indoles via Neighboring Aldehyde Group Assisted Catellani Reaction.

Site-Selective Synthesis of Antitumor C5-Aminated Indoles via Neighboring Aldehyde Group Assisted Catellani Reaction.

Journal: Organic letters

Published: December 18, 2023

Transient Directing Group Strategy as a Unified Method for Site Selective Direct C4-H Halogenation of Indoles.

Transient Directing Group Strategy as a Unified Method for Site Selective Direct C4-H Halogenation of Indoles.

Journal: Organic letters

Published: October 19, 2021

Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction.

Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction.

Journal: Bioorganic chemistry

Published: October 04, 2021

Showing 1-10 of 10

Last Updated: 09/26/2026