Guillermo A. Senisterra

101 College Street
Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 25 publications

Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.

Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.

Journal: ChemMedChem

Published: June 15, 2021

Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.

Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.

Journal: ACS medicinal chemistry letters

Published: April 14, 2020

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: June 27, 2019

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Journal: Nature chemical biology

Published: March 08, 2019

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.

Journal: SLAS discovery : advancing life sciences R & D

Published: March 23, 2018

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Journal: Nature chemical biology

Published: August 31, 2017

Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.

Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.

Journal: The Journal of biological chemistry

Published: May 31, 2017

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

Journal: Journal of medicinal chemistry

Published: September 02, 2016

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Journal: Nature chemical biology

Published: July 14, 2016

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

Journal: Journal of medicinal chemistry

Published: March 10, 2016

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

Journal: Journal of medicinal chemistry

Published: January 30, 2016

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Journal: ACS chemical biology

Published: November 25, 2015

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Last Updated: 09/26/2026