Guo-bo D. Li

Key Laboratory Of Drug Targeting And Drug Delivery System Of The Education Ministry And Sichuan Province
610041, China

Last Updated: 09/26/2026

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Found 59 publications

Iterative Interaction Fingerprints-Guided Multiobjective Molecular Generation.

Iterative Interaction Fingerprints-Guided Multiobjective Molecular Generation.

Journal: Journal of chemical information and modeling

Published: July 14, 2026

X-ray Crystallography-Guided Discovery of a Potent Dual-Pocket Competitive SIRT5 Inhibitor against Sepsis-Associated AKI.

X-ray Crystallography-Guided Discovery of a Potent Dual-Pocket Competitive SIRT5 Inhibitor against Sepsis-Associated AKI.

Journal: Journal of medicinal chemistry

Published: May 17, 2026

A Novel CSN5 Inhibitor Drives Tumor-Intrinsic PD-L1 Degradation and Exerts Direct Antitumor Efficacy in Triple-Negative Breast Cancer.

A Novel CSN5 Inhibitor Drives Tumor-Intrinsic PD-L1 Degradation and Exerts Direct Antitumor Efficacy in Triple-Negative Breast Cancer.

Journal: Journal of medicinal chemistry

Published: February 18, 2026

Structural Optimization of Benzyl-5-methyl‑1H‑Imidazole Derivatives as Human Glutaminyl Cyclase Inhibitors.

Structural Optimization of Benzyl-5-methyl‑1H‑Imidazole Derivatives as Human Glutaminyl Cyclase Inhibitors.

Journal: ACS medicinal chemistry letters

Published: January 13, 2026

Evolution of Molecular Generation Models in Drug Discovery.

Evolution of Molecular Generation Models in Drug Discovery.

Journal: Journal of medicinal chemistry

Published: January 09, 2026

Structural Optimization of Bicyclic Oxo-Boronates as Dual Metallo- and Serine-β-Lactamase Inhibitors.

Structural Optimization of Bicyclic Oxo-Boronates as Dual Metallo- and Serine-β-Lactamase Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 13, 2025

Design, synthesis and biological evaluation of novel glutaminyl cyclase inhibitors targeting the CD47-SIRPα axis in breast cancer cells.

Design, synthesis and biological evaluation of novel glutaminyl cyclase inhibitors targeting the CD47-SIRPα axis in breast cancer cells.

Journal: Bioorganic & medicinal chemistry

Published: August 12, 2025

Bacteriophage-mediated antibacterial and photodynamic therapies.

Bacteriophage-mediated antibacterial and photodynamic therapies.

Journal: RSC medicinal chemistry

Published: July 28, 2025

Co-delivery of SN38 and SR717 activates cGAS-STING for near-infrared II image-guided chemoimmunotherapy.

Co-delivery of SN38 and SR717 activates cGAS-STING for near-infrared II image-guided chemoimmunotherapy.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Published: June 15, 2025

Deciphering Glutaminyl Cyclase Catalytic Pathways Enables Recognition of Anchor Pharmacophores for Inhibitor Discovery.

Deciphering Glutaminyl Cyclase Catalytic Pathways Enables Recognition of Anchor Pharmacophores for Inhibitor Discovery.

Journal: Journal of chemical information and modeling

Published: May 14, 2025

Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels.

Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels.

Journal: Medicinal research reviews

Published: May 07, 2025

A 3D pocket-aware lead optimization model with knowledge guidance and its application for discovery of new glutaminyl cyclase inhibitors.

A 3D pocket-aware lead optimization model with knowledge guidance and its application for discovery of new glutaminyl cyclase inhibitors.

Journal: Briefings in bioinformatics

Published: March 25, 2025

Showing 1-12 of 59

Last Updated: 09/26/2026