Guowen Ren

Shenzhen, 518055, China

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 14 publications

ARID1A deficiency activates OSM-STAT3 axis in endometrial cancer, creating vulnerability to JAK/STAT3 inhibition.

ARID1A deficiency activates OSM-STAT3 axis in endometrial cancer, creating vulnerability to JAK/STAT3 inhibition.

Journal: International journal of biological sciences

Published: November 28, 2025

DNA methyltransferase inhibition is a therapeutic vulnerability in VHL-deficient renal cell carcinoma cells.

DNA methyltransferase inhibition is a therapeutic vulnerability in VHL-deficient renal cell carcinoma cells.

Journal: Experimental & molecular medicine

Published: September 03, 2025

PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition.

PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition.

Journal: International journal of biological sciences

Published: January 28, 2025

Microtubule dynamics is a therapeutic vulnerability in VHL-deficient renal cell carcinoma.

Microtubule dynamics is a therapeutic vulnerability in VHL-deficient renal cell carcinoma.

Journal: International journal of biological sciences

Published: December 30, 2024

Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair.

Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair.

Journal: Experimental & molecular medicine

Published: May 14, 2024

BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1.

BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1.

Journal: International journal of biological sciences

Published: November 03, 2023

MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism.

MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism.

Journal: International journal of biological sciences

Published: January 11, 2023

ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones.

ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones.

Journal: International journal of biological sciences

Published: December 20, 2022

Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation.

Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation.

Journal: Oncogene

Published: November 08, 2021

Natural products targeting cancer cell dependency.

Natural products targeting cancer cell dependency.

Journal: The Journal of antibiotics

Published: April 29, 2021

Aurora kinase A, a synthetic lethal target for precision cancer medicine.

Aurora kinase A, a synthetic lethal target for precision cancer medicine.

Journal: Experimental & molecular medicine

Published: February 05, 2021

Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression.

Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression.

Journal: Oncogene

Published: August 13, 2020

Showing 1-12 of 14

Last Updated: 09/26/2026