Han-jou Chen

York, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 17 publications

Targeting the activation heat shock proteins for the potential treatment of neurodegenerative disease.

Targeting the activation heat shock proteins for the potential treatment of neurodegenerative disease.

Journal: Expert opinion on therapeutic targets

Published: December 22, 2025

Crossroad of motor neuron disease and dementia: Insights from TDP-43 RNA-binding deficiency.

Crossroad of motor neuron disease and dementia: Insights from TDP-43 RNA-binding deficiency.

Journal: Neural regeneration research

Published: August 28, 2025

Familial ALS/FTD-associated RNA-binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitro.

Familial ALS/FTD-associated RNA-binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitro.

Journal: Human molecular genetics

Published: March 17, 2025

Identification of novel small molecule chaperone activators for neurodegenerative disease treatment.

Identification of novel small molecule chaperone activators for neurodegenerative disease treatment.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: January 10, 2025

Mechanisms of TDP-43 Proteinopathy Onset and Propagation.

Mechanisms of TDP-43 Proteinopathy Onset and Propagation.

Journal: International journal of molecular sciences

Published: April 30, 2021

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

Journal: Human molecular genetics

Published: January 09, 2020

RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy.

RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy.

Journal: Brain : a journal of neurology

Published: March 29, 2019

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function.

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function.

Journal: Neurobiology of aging

Published: April 18, 2018

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

Journal: Human molecular genetics

Published: June 28, 2017

Reply: The role of DNAJB2 in amyotrophic lateral sclerosis.

Reply: The role of DNAJB2 in amyotrophic lateral sclerosis.

Journal: Brain : a journal of neurology

Published: June 23, 2016

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Journal: Science translational medicine

Published: November 26, 2015

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis.

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis.

Journal: Brain : a journal of neurology

Published: September 07, 2015

Showing 1-12 of 17

Last Updated: 09/26/2026