Hans-gunter Zerwes

Basel, BS, Switzerland

Last Updated: 09/26/2026

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Found 13 publications

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds.

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds.

Journal: Experimental dermatology

Published: November 30, 2023

Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

Journal: Journal of medicinal chemistry

Published: October 31, 2023

Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation.

Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation.

Journal: ACS medicinal chemistry letters

Published: April 26, 2023

Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis.

Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis.

Journal: Journal of medicinal chemistry

Published: January 19, 2023

Ligelizumab treatment for severe asthma: learnings from the clinical development programme.

Ligelizumab treatment for severe asthma: learnings from the clinical development programme.

Journal: Clinical & translational immunology

Published: May 07, 2020

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.

Journal: Arthritis & rheumatology (Hoboken, N.J.)

Published: October 20, 2019

A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation.

A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation.

Journal: The Journal of investigative dermatology

Published: October 15, 2017

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.

Journal: Bioorganic & medicinal chemistry letters

Published: August 05, 2015

Discovery and profiling of a selective and efficacious Syk inhibitor.

Discovery and profiling of a selective and efficacious Syk inhibitor.

Journal: Journal of medicinal chemistry

Published: January 31, 2015

Selective inhibitors of the Janus kinase Jak3--Are they effective?

Selective inhibitors of the Janus kinase Jak3--Are they effective?

Journal: Bioorganic & medicinal chemistry letters

Published: August 02, 2014

Syk inhibitors with high potency in presence of blood.

Syk inhibitors with high potency in presence of blood.

Journal: Bioorganic & medicinal chemistry letters

Published: March 05, 2014

Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions.

Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions.

Journal: Blood

Published: April 06, 2013

Showing 1-12 of 13

Last Updated: 09/26/2026