Hanzi Sun

Beijing, China

Last Updated: 09/26/2026

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Found 9 publications

Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.

Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.

Journal: Journal of medicinal chemistry
Published: May 02, 2024

Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity.

Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity.

Journal: mAbs
Published: May 25, 2023

Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases.

Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases.

Journal: Journal of medicinal chemistry
Published: March 13, 2023

Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.

Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.

Journal: Blood
Published: January 20, 2023

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models.

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models.

Journal: Frontiers of medicine
Published: October 14, 2022

Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles.

Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles.

Journal: Molecular pharmaceutics
Published: August 23, 2017

A motif in LILRB2 critical for Angptl2 binding and activation.

A motif in LILRB2 critical for Angptl2 binding and activation.

Journal: Blood
Published: June 06, 2014

A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.

A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.

Journal: PLoS genetics
Published: October 22, 2013

Incorporating replacement free energy of binding-site waters in molecular docking.

Incorporating replacement free energy of binding-site waters in molecular docking.

Journal: Proteins
Published: October 08, 2013
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Last Updated: 09/26/2026