Haoyu Ye

Chengdu, 610041, China

Last Updated: 09/26/2026

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Found 73 publications

Elimination of Senescent Macrophages by Purinergic Receptor P2RX7 Antagonist to Safeguard Against Kidney Injury and Aging.

Elimination of Senescent Macrophages by Purinergic Receptor P2RX7 Antagonist to Safeguard Against Kidney Injury and Aging.

Journal: International journal of biological sciences

Published: May 25, 2026

Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis.

Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis.

Journal: Journal of pharmaceutical analysis

Published: June 30, 2025

VCP's nuclear journey: Initiated by interacting with KPNB1 to repair DNA damage.

VCP's nuclear journey: Initiated by interacting with KPNB1 to repair DNA damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: May 08, 2025

Molecular basis of two broad-spectrum antibodies neutralizing rabies virus and other phylogroup-I lyssaviruses by blocking structural transition between the pleckstrin-homology and fusion domains in the glycoprotein.

Molecular basis of two broad-spectrum antibodies neutralizing rabies virus and other phylogroup-I lyssaviruses by blocking structural transition between the pleckstrin-homology and fusion domains in the glycoprotein.

Journal: International journal of biological macromolecules

Published: January 06, 2025

Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease.

Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease.

Journal: Journal of medicinal chemistry

Published: September 23, 2024

Structures of two lyssavirus glycoproteins trapped in pre- and post-fusion states and the implications on the spatial-temporal conformational transition along with pH-decrease.

Structures of two lyssavirus glycoproteins trapped in pre- and post-fusion states and the implications on the spatial-temporal conformational transition along with pH-decrease.

Journal: PLoS pathogens

Published: August 27, 2024

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms.

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms.

Journal: Blood cancer journal

Published: June 26, 2024

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.

Journal: Science advances

Published: February 07, 2024

Rational construction of genome-minimized Streptomyces host for the expression of secondary metabolite gene clusters.

Rational construction of genome-minimized Streptomyces host for the expression of secondary metabolite gene clusters.

Journal: Synthetic and systems biotechnology

Published: February 04, 2024

Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers.

Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers.

Journal: Journal of medicinal chemistry

Published: December 20, 2023

Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.

Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.

Journal: Journal of medicinal chemistry

Published: October 25, 2023

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis.

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis.

Journal: Journal of medicinal chemistry

Published: September 27, 2023

Showing 1-12 of 73

Last Updated: 09/26/2026