Haruhide Kimura
Fujisawa, 2518555, Japan
Last Updated: 09/26/2026
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Found 65 publications
Effects of an orexin receptor 2-selective agonist on salivary secretion in rats.
Journal: Scientific reports
Published: January 08, 2026
Drug discovery strategy for TAK-418, a specific inhibitor of LSD1 enzyme activity, as a novel therapy for autism.
Journal: Advances in pharmacology (San Diego, Calif.)
Published: February 10, 2025
M1 receptor positive allosteric modulators discovery approaches.
Journal: Trends in pharmacological sciences
Published: February 03, 2025
An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions.
Journal: Current biology : CB
Published: November 15, 2024
TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models.
Journal: Scientific reports
Published: May 15, 2024
Effects of an OX2R agonist on migration and removal of tau from mouse brain.
Journal: Scientific reports
Published: February 22, 2024
The orexin receptor 2 (OX2R)-selective agonist TAK-994 increases wakefulness without affecting cerebrospinal fluid orexin levels in cynomolgus monkeys.
Journal: Pharmacology, biochemistry, and behavior
Published: November 14, 2023
Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys.
Journal: British journal of anaesthesia
Published: July 11, 2023
Diurnal Fluctuations of Orexin-A and -B in Cynomolgus Monkey Cerebrospinal Fluid Determined by a Novel Analytical Method Using Antiadsorptive Additive Treatment Followed by Nanoflow Liquid Chromatography-High-Resolution Mass Spectrometry.
Journal: ACS chemical neuroscience
Published: January 31, 2023
Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals.
Journal: Journal of sleep research
Published: November 10, 2022
Role of the AMPA receptor in antidepressant effects of ketamine and potential of AMPA receptor potentiators as a novel antidepressant.
Journal: Neuropharmacology
Published: September 17, 2022
Last Updated: 09/26/2026