Heather P. Harding
Cambridge, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 41 publications
Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress.
Journal: Life science alliance
Published: February 26, 2026
A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.
Journal: Nature communications
Published: February 13, 2025
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α.
Journal: eLife
Published: July 29, 2024
Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells.
Journal: STAR protocols
Published: June 11, 2024
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: March 28, 2024
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.
Journal: EMBO molecular medicine
Published: June 24, 2022
Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Journal: Nature structural & molecular biology
Published: April 22, 2021
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers.
Journal: Cell reports
Published: October 01, 2020
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Journal: Molecular cell
Published: June 30, 2020
Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.
Journal: Nature
Published: February 14, 2020
Last Updated: 09/26/2026