Heiko Kroth
Lausanne, VD 1015, Switzerland
Last Updated: 09/26/2026
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Found 11 publications
Radiosynthesis, In Vitro Characterization, and In Vivo PET Neuroimaging of [18F]F-4 for Tau Protein: A First-in-Human PET Study.
Journal: ACS chemical neuroscience
Published: March 10, 2025
Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology.
Journal: Nature communications
Published: November 25, 2024
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Journal: Bioorganic & medicinal chemistry
Published: September 09, 2021
PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
Journal: Journal of medicinal chemistry
Published: August 30, 2021
Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
Journal: European journal of medicinal chemistry
Published: April 17, 2020
Evaluation of Dosimetry, Quantitative Methods, and Test-Retest Variability of 18F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Published: September 06, 2019
Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Published: September 06, 2019
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Journal: European journal of nuclear medicine and molecular imaging
Published: December 11, 2018
Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters
Published: December 14, 2016
Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation.
Journal: Bioorganic & medicinal chemistry letters
Published: March 21, 2016
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.
Journal: The Journal of biological chemistry
Published: August 15, 2012
Showing 1-11 of 11
Last Updated: 09/26/2026