Helen F. Small

Alderley Park
Macclesfield, ENG SK104TG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Journal: Bioorganic & medicinal chemistry letters

Published: November 13, 2018

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Journal: Journal of medicinal chemistry

Published: November 08, 2018

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.

Journal: Bioorganic & medicinal chemistry letters

Published: March 30, 2017

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

Journal: Journal of medicinal chemistry

Published: December 23, 2016

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.

Journal: ACS chemical biology

Published: October 01, 2016

Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.

Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.

Journal: Endocrinology

Published: September 21, 2016

Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.

Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.

Journal: F1000Research

Published: July 19, 2016

Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.

Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.

Journal: Bioorganic & medicinal chemistry letters

Published: February 04, 2016

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.

Journal: European journal of medicinal chemistry

Published: August 27, 2015

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.

Journal: British journal of haematology

Published: March 11, 2014

Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.

Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.

Journal: Journal of medicinal chemistry

Published: July 18, 2013

Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.

Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.

Journal: Journal of medicinal chemistry

Published: April 18, 2012

Showing 1-12 of 12

Last Updated: 09/26/2026