Helen L. Tuppen

Framlington Place
Newcastle Upon Tyne, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 19 publications

Mavodelpar in patients with primary mitochondrial myopathy: a phase 1 trial.

Mavodelpar in patients with primary mitochondrial myopathy: a phase 1 trial.

Journal: Scientific reports

Published: December 11, 2025

Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes.

Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes.

Journal: Aging cell

Published: January 03, 2025

Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study.

Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study.

Journal: GeroScience

Published: November 29, 2024

Variant load of mitochondrial DNA in single human mesenchymal stem cells.

Variant load of mitochondrial DNA in single human mesenchymal stem cells.

Journal: Scientific reports

Published: July 23, 2024

A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults.

A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults.

Journal: BMJ open

Published: February 28, 2024

Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease.

Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease.

Journal: Communications biology

Published: February 27, 2024

Resistance Exercise Training Rescues Mitochondrial Dysfunction in Skeletal Muscle of Patients with Myotonic Dystrophy Type 1.

Resistance Exercise Training Rescues Mitochondrial Dysfunction in Skeletal Muscle of Patients with Myotonic Dystrophy Type 1.

Journal: Journal of neuromuscular diseases

Published: August 28, 2023

Single Cell Analysis of Mitochondrial DNA Deletions.

Single Cell Analysis of Mitochondrial DNA Deletions.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: February 22, 2023

Correction: Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy.

Correction: Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy.

Journal: Trials

Published: October 05, 2022

Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy.

Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy.

Journal: Trials

Published: April 25, 2022

Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level.

Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level.

Journal: Nucleic acids research

Published: March 27, 2019

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

Journal: Clinical science (London, England : 1979)

Published: January 29, 2015

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Last Updated: 09/26/2026