Helene Haegel

Basel, BS, Switzerland

Last Updated: 09/26/2026

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Found 17 publications

Patient-Centric First-in-Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T-Cell Engagers in Multiple Myeloma.

Patient-Centric First-in-Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T-Cell Engagers in Multiple Myeloma.

Journal: Clinical pharmacology and therapeutics

Published: March 07, 2026

Transient prophylactic immunosuppression with abatacept or dasatinib prevents immune responses in AAV gene transfer.

Transient prophylactic immunosuppression with abatacept or dasatinib prevents immune responses in AAV gene transfer.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: October 23, 2025

Spatial transcriptomics and single-nucleus RNA sequencing reveal rAAV2- and rAAV9-specific transduction signatures in the mouse liver.

Spatial transcriptomics and single-nucleus RNA sequencing reveal rAAV2- and rAAV9-specific transduction signatures in the mouse liver.

Journal: Gene therapy

Published: April 16, 2025

Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release.

Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release.

Journal: Molecular therapy. Methods & clinical development

Published: December 13, 2024

Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy.

Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy.

Journal: Scientific reports

Published: June 11, 2024

Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies.

Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: December 02, 2022

Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors.

Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors.

Journal: Oncoimmunology

Published: June 13, 2022

Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils.

Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils.

Journal: Oncoimmunology

Published: February 21, 2022

JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy.

JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy.

Journal: Journal for immunotherapy of cancer

Published: December 11, 2021

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.

Journal: Journal for immunotherapy of cancer

Published: July 05, 2021

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models.

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models.

Journal: Investigative ophthalmology & visual science

Published: June 04, 2018

TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.

TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.

Journal: British journal of cancer

Published: May 02, 2018

Showing 1-12 of 17

Last Updated: 09/26/2026