Helene Thibault-Cwerman

Paris, 75019, France

Last Updated: 09/26/2026

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Found 9 publications

Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior.

Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: December 12, 2023

Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor.

Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: November 10, 2023

Neuroglobin effectively halts vision loss in Harlequin mice at an advanced stage of optic nerve degeneration.

Neuroglobin effectively halts vision loss in Harlequin mice at an advanced stage of optic nerve degeneration.

Journal: Neurobiology of disease

Published: January 28, 2021

Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice.

Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice.

Journal: Molecular therapy. Methods & clinical development

Published: October 26, 2016

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.

Journal: Molecular therapy. Methods & clinical development

Published: October 01, 2014

Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.

Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: January 23, 2014

Gene therapy for mitochondrial diseases: Leber Hereditary Optic Neuropathy as the first candidate for a clinical trial.

Gene therapy for mitochondrial diseases: Leber Hereditary Optic Neuropathy as the first candidate for a clinical trial.

Journal: Comptes rendus biologies

Published: November 28, 2013

Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity.

Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity.

Journal: Biochimica et biophysica acta

Published: August 01, 2012

Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy.

Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy.

Journal: Brain : a journal of neurology

Published: November 29, 2011

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Last Updated: 09/26/2026