Hella Kohlhof

Grafelfing, BY, Germany

Last Updated: 09/26/2026

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Found 37 publications

Vidofludimus calcium for the treatment of multiple sclerosis: development rationale, mechanism of action, and early trial data.

Vidofludimus calcium for the treatment of multiple sclerosis: development rationale, mechanism of action, and early trial data.

Journal: Expert opinion on investigational drugs
Published: July 16, 2026

DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.

DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.

Journal: Journal of medicinal chemistry
Published: June 03, 2026

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity.

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity.

Journal: bioRxiv : the preprint server for biology
Published: April 27, 2026

Development of a Brain-Penetrant Nurr1 Agonist Tool.

Development of a Brain-Penetrant Nurr1 Agonist Tool.

Journal: ChemMedChem
Published: January 08, 2026

Carboxylic Acid Bioisosteres Boost Nurr1 Agonist Selectivity.

Carboxylic Acid Bioisosteres Boost Nurr1 Agonist Selectivity.

Journal: Journal of medicinal chemistry
Published: July 17, 2025

An Open-label, Phase 1 Dose-finding Study of Single-agent IMU-935, a Novel RORγ/RORγt Inverse Agonist, in Patients with Progressive Metastatic Castration-resistant Prostate Cancer.

An Open-label, Phase 1 Dose-finding Study of Single-agent IMU-935, a Novel RORγ/RORγt Inverse Agonist, in Patients with Progressive Metastatic Castration-resistant Prostate Cancer.

Journal: European urology oncology
Published: July 14, 2025

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes.

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes.

Journal: Molecular metabolism
Published: June 18, 2025

Lost in translation: rethinking animal models of progressive MS (an industry perspective).

Lost in translation: rethinking animal models of progressive MS (an industry perspective).

Journal: Multiple sclerosis and related disorders
Published: May 30, 2025

Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development.

Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development.

Journal: The Journal of clinical investigation
Published: August 12, 2024

Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity.

Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity.

Journal: Antiviral research
Published: July 19, 2024

Vidofludimus Calcium in Patients With Moderate-to-Severe Ulcerative Colitis: A Randomized, Placebo-Controlled, Phase 2 Trial.

Vidofludimus Calcium in Patients With Moderate-to-Severe Ulcerative Colitis: A Randomized, Placebo-Controlled, Phase 2 Trial.

Journal: Clinical and translational gastroenterology
Published: July 15, 2024

Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses.

Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses.

Journal: Antiviral research
Published: June 10, 2024
Showing 1-12 of 37

Last Updated: 09/26/2026