Herman Borghys

Janssen R&D
Beerse, VLG, Belgium

Last Updated: 09/26/2026

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Found 24 publications

Tissue Penetration of Gemcitabine and Gemcitabine Phosphate Metabolites Following Gemcitabine Intravesical System Administration Versus Standard Intravesical Instillation in a Preclinical Minipig Model.

Tissue Penetration of Gemcitabine and Gemcitabine Phosphate Metabolites Following Gemcitabine Intravesical System Administration Versus Standard Intravesical Instillation in a Preclinical Minipig Model.

Journal: European urology focus

Published: November 26, 2025

Middle-aged dogs with low and high Aβ CSF concentrations show differences in energy and stress related metabolic profiles in CSF.

Middle-aged dogs with low and high Aβ CSF concentrations show differences in energy and stress related metabolic profiles in CSF.

Journal: Heliyon

Published: January 19, 2024

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: September 23, 2021

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats.

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats.

Journal: Drug delivery

Published: November 10, 2020

Use of the Actiwatch-Mini® in dog safety studies as an early indicator for drug-induced behavioural changes.

Use of the Actiwatch-Mini® in dog safety studies as an early indicator for drug-induced behavioural changes.

Journal: Journal of pharmacological and toxicological methods

Published: December 05, 2019

Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

Journal: Journal of medicinal chemistry

Published: September 25, 2019

Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden.

Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden.

Journal: ChemMedChem

Published: August 17, 2019

Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.

Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.

Journal: Bioorganic & medicinal chemistry letters

Published: March 18, 2019

Correction to Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Correction to Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: December 12, 2018

Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: May 29, 2018

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Journal: Journal of medicinal chemistry

Published: May 19, 2018

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

Journal: Journal of medicinal chemistry

Published: May 08, 2018

Showing 1-12 of 24

Last Updated: 09/26/2026