Heyao Wang

State Key Laboratory Of Drug Research
Shanghai, 201203, China

Last Updated: 09/26/2026

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Found 22 publications

Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation-Related Diseases.

Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation-Related Diseases.

Journal: Journal of medicinal chemistry

Published: September 24, 2025

Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury.

Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: August 04, 2024

Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation.

Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation.

Journal: European journal of medicinal chemistry

Published: February 13, 2023

Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice.

Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice.

Journal: The Journal of endocrinology

Published: October 15, 2018

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design.

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design.

Journal: Bioorganic & medicinal chemistry letters

Published: April 23, 2018

Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay.

Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay.

Journal: Scientific reports

Published: February 16, 2016

Preparation of Methylated Products of A-type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β-Cell.

Preparation of Methylated Products of A-type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β-Cell.

Journal: Journal of food science

Published: October 24, 2015

Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress.

Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress.

Journal: PloS one

Published: March 11, 2015

Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.

Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.

Journal: Archiv der Pharmazie

Published: March 02, 2015

Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors.

Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors.

Journal: ACS medicinal chemistry letters

Published: February 15, 2015

Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.

Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.

Journal: Journal of medicinal chemistry

Published: September 03, 2014

Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination.

Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination.

Journal: European journal of medicinal chemistry

Published: July 03, 2014

Showing 1-12 of 22

Last Updated: 09/26/2026