Hiroki Akiba

Osaka, Japan

Last Updated: 09/26/2026

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Found 36 publications

Systematic Production of IgG-Like Bispecific Antibodies via Intein-Mediated Protein Trans-Splicing.

Systematic Production of IgG-Like Bispecific Antibodies via Intein-Mediated Protein Trans-Splicing.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: May 13, 2026

Multimodal Physicochemical Characterization of Cross-Linking Activities of Biparatopic Antibodies.

Multimodal Physicochemical Characterization of Cross-Linking Activities of Biparatopic Antibodies.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: May 10, 2026

Influence of the Binding Valency of Anti-HER2 Biparatopic Antibodies on Biodistribution in an SK-OV-3 Tumor Xenograft Model.

Influence of the Binding Valency of Anti-HER2 Biparatopic Antibodies on Biodistribution in an SK-OV-3 Tumor Xenograft Model.

Journal: Molecular pharmaceutics

Published: March 24, 2026

Beyond Borders: Next-generation Technologies for Analytical Chemistry and Drug Development

Beyond Borders: Next-generation Technologies for Analytical Chemistry and Drug Development

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Published: June 01, 2025

Design Strategy of Antibody Pairs for Biepitopic Antigen-Templated Chemical Reaction Depending on the Tertiary Structure of the Antigen.

Design Strategy of Antibody Pairs for Biepitopic Antigen-Templated Chemical Reaction Depending on the Tertiary Structure of the Antigen.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: May 22, 2025

Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region.

Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region.

Journal: The Journal of biological chemistry

Published: April 30, 2025

Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling.

Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling.

Journal: Chemical communications (Cambridge, England)

Published: April 01, 2025

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule.

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule.

Journal: Antibody therapeutics

Published: August 12, 2024

Unveiling the structural mechanisms behind high affinity and selectivity in phosphorylated epitope-specific rabbit antibodies.

Unveiling the structural mechanisms behind high affinity and selectivity in phosphorylated epitope-specific rabbit antibodies.

Journal: The Journal of biological chemistry

Published: July 16, 2024

A Proximity-Induced Fluorogenic Reaction Triggered by Antibody-Antigen Interactions with Adjacent Epitopes.

A Proximity-Induced Fluorogenic Reaction Triggered by Antibody-Antigen Interactions with Adjacent Epitopes.

Journal: Angewandte Chemie (International ed. in English)

Published: May 08, 2023

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.

Journal: Communications biology

Published: March 07, 2023

Development of a recombinant hepatitis B immunoglobulin derived from B cells collected from healthy individuals administered with hepatitis B virus vaccines: A feasibility study.

Development of a recombinant hepatitis B immunoglobulin derived from B cells collected from healthy individuals administered with hepatitis B virus vaccines: A feasibility study.

Journal: Transfusion

Published: January 29, 2023

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Last Updated: 09/26/2026