Hiroshi Shima

Japan

Last Updated: 09/26/2026

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Found 41 publications

Protein phosphatase 6 protects hepatocytes from endoplasmic reticulum and oxidative stress by suppressing Akt/mTOR signaling.

Protein phosphatase 6 protects hepatocytes from endoplasmic reticulum and oxidative stress by suppressing Akt/mTOR signaling.

Journal: Biochemical and biophysical research communications

Published: February 09, 2026

Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.

Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.

Journal: Experimental hematology

Published: November 24, 2023

Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.

Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.

Journal: Biochemical and biophysical research communications

Published: November 21, 2023

Oncogenic K-RasG12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.

Oncogenic K-RasG12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.

Journal: FEBS open bio

Published: September 28, 2023

Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.

Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.

Journal: Nature communications

Published: April 18, 2023

Clinical and genomic features of non-small cell lung cancer occurring in families.

Clinical and genomic features of non-small cell lung cancer occurring in families.

Journal: Thoracic cancer

Published: December 11, 2022

Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.

Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.

Journal: The Journal of steroid biochemistry and molecular biology

Published: February 02, 2022

A novel 8.57-kb deletion of the upstream region of PRKAR1A in a family with Carney complex.

A novel 8.57-kb deletion of the upstream region of PRKAR1A in a family with Carney complex.

Journal: Molecular genetics & genomic medicine

Published: November 25, 2021

PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.

PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.

Journal: Cancer science

Published: October 14, 2021

Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125.

Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125.

Journal: Gynecologic oncology reports

Published: June 08, 2021

Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens.

Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens.

Journal: Anticancer research

Published: December 28, 2020

Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis.

Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis.

Journal: Cancer medicine

Published: December 07, 2020

Showing 1-12 of 41

Last Updated: 09/26/2026