Hisato Hirano
Tokyo, Japan
Last Updated: 09/26/2026
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Found 18 publications
Structure and evolution of the sequence-specific anti-silencing factor VANC21 and its target DNA.
Journal: Genes & genetic systems
Published: November 19, 2025
Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation.
Journal: Nature communications
Published: September 14, 2025
Expanded genetic alphabet increases structural and chemical diversity of six-letter DNA for high-affinity protein-targeting aptamers.
Journal: Nature communications
Published: March 28, 2025
Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ2.
Journal: Communications biology
Published: December 03, 2024
Structural insights into how Cas9 targets nucleosomes.
Journal: Nature communications
Published: April 11, 2024
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R.
Journal: Nature chemical biology
Published: January 20, 2024
Structural basis for pegRNA-guided reverse transcription by a prime editor.
Journal: Nature
Published: October 24, 2023
Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme.
Journal: Nature structural & molecular biology
Published: February 07, 2023
Cryo-EM structure of the transposon-associated TnpB enzyme.
Journal: Nature
Published: October 04, 2022
Structure and engineering of the minimal type VI CRISPR-Cas13bt3.
Journal: Molecular cell
Published: November 16, 2021
Structure of the type V-C CRISPR-Cas effector enzyme.
Journal: Molecular cell
Published: August 28, 2021
Last Updated: 09/26/2026