Hitomi Nakamura

Nishi, 8600082, Japan

Last Updated: 09/26/2026

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Found 32 publications

Position-dependent effects of loop proline residues on Fab stability and aggregation.

Position-dependent effects of loop proline residues on Fab stability and aggregation.

Journal: Biochemical and biophysical research communications

Published: April 16, 2026

Juvenile-specific expression of a phospholipase A2 isozyme gene in the venom gland of Protobothrops flavoviridis.

Juvenile-specific expression of a phospholipase A2 isozyme gene in the venom gland of Protobothrops flavoviridis.

Journal: Toxicon : official journal of the International Society on Toxinology

Published: October 08, 2025

Chimeric Fab incorporating the IgM Cμ1 domain: insights into physicochemical properties.

Chimeric Fab incorporating the IgM Cμ1 domain: insights into physicochemical properties.

Journal: Journal of biochemistry

Published: September 24, 2025

Characterization of adalimumab Fab variants with the CH1 domain replaced by the Cα1 domain of IgA.

Characterization of adalimumab Fab variants with the CH1 domain replaced by the Cα1 domain of IgA.

Journal: Biochemistry and biophysics reports

Published: August 13, 2025

Fundamental Research into Enhancing Fab Functionality by Protein Engineering

Fundamental Research into Enhancing Fab Functionality by Protein Engineering

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Published: April 30, 2025

Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains.

Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains.

Journal: Biochemical and biophysical research communications

Published: January 25, 2024

Enhancing thermal stability in the CH2 domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris.

Enhancing thermal stability in the CH2 domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris.

Journal: Protein science : a publication of the Protein Society

Published: September 05, 2023

Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab.

Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab.

Journal: Journal of biochemistry

Published: March 17, 2023

An In Vivo Screening Model for Investigation of Pathophysiology of Human Implantation Failure.

An In Vivo Screening Model for Investigation of Pathophysiology of Human Implantation Failure.

Journal: Biomolecules

Published: October 05, 2022

Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity.

Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity.

Journal: Journal of biochemistry

Published: February 18, 2022

A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab.

A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab.

Journal: Scientific reports

Published: March 03, 2021

Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris.

Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris.

Journal: Journal of biochemistry

Published: September 09, 2020

Showing 1-12 of 32

Last Updated: 09/26/2026