Holly A. Saffran

Edmonton, AB T6G2H7, Canada

Last Updated: 09/26/2026

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Found 21 publications

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor.

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor.

Journal: Journal of medicinal chemistry
Published: July 16, 2026

Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease.

Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease.

Journal: ACS medicinal chemistry letters
Published: September 05, 2024

Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.

Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.

Journal: Journal of thrombosis and haemostasis : JTH
Published: July 26, 2024

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

Journal: ACS bio & med chem Au
Published: June 28, 2023

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection.

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection.

Journal: Frontiers in immunology
Published: April 27, 2022

Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters.

Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters.

Journal: NPJ vaccines
Published: August 01, 2021

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

Journal: RSC medicinal chemistry
Published: July 22, 2021

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.

Journal: Journal of medicinal chemistry
Published: July 09, 2021

SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1.

SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1.

Journal: Vaccine
Published: June 25, 2021

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.

Journal: European journal of medicinal chemistry
Published: March 15, 2021

Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2.

Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2.

Journal: Clinical & translational immunology
Published: December 22, 2020

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.

Journal: Nature communications
Published: October 21, 2020
Showing 1-12 of 21

Last Updated: 09/26/2026