Holly Spence

Aberdeen, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 13 publications

Metabolic signatures of ferritin and TDP-43 co-pathology provide a mechanistic basis for stratified therapeutic approaches in ALS.

Metabolic signatures of ferritin and TDP-43 co-pathology provide a mechanistic basis for stratified therapeutic approaches in ALS.

Journal: bioRxiv : the preprint server for biology

Published: March 27, 2026

TDP-43 pathology is linked to motor neuron loss and is independent of stress granules in vivo.

TDP-43 pathology is linked to motor neuron loss and is independent of stress granules in vivo.

Journal: bioRxiv : the preprint server for biology

Published: February 23, 2026

Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis.

Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis.

Journal: bioRxiv : the preprint server for biology

Published: November 19, 2025

Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset.

Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset.

Journal: bioRxiv : the preprint server for biology

Published: November 19, 2025

Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function.

Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function.

Journal: bioRxiv : the preprint server for biology

Published: January 27, 2025

Improving ALS detection and cognitive impairment stratification with attention-enhanced deep learning models.

Improving ALS detection and cognitive impairment stratification with attention-enhanced deep learning models.

Journal: Scientific reports

Published: November 13, 2024

Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.

Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.

Journal: Brain communications

Published: November 07, 2024

Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.

Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.

Journal: Nature communications

Published: August 22, 2024

Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.

Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.

Journal: bioRxiv : the preprint server for biology

Published: June 10, 2024

Associations between sex, systemic iron and inflammatory status and subcortical brain iron.

Associations between sex, systemic iron and inflammatory status and subcortical brain iron.

Journal: The European journal of neuroscience

Published: January 12, 2024

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.

Journal: Acta neuropathologica

Published: November 28, 2023

Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields.

Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields.

Journal: The European journal of neuroscience

Published: July 29, 2022

Showing 1-12 of 13

Last Updated: 09/26/2026