Hong-yu Hu

Key Laboratory Of RNA Innovation
Shanghai, 200031, China

Last Updated: 09/26/2026

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Found 42 publications

Suppressing the Aberrant Transcriptional Functionality of EWS::FLI1 Oncoprotein by Designer polyQ Fusions with Its Homologous Peptides.

Suppressing the Aberrant Transcriptional Functionality of EWS::FLI1 Oncoprotein by Designer polyQ Fusions with Its Homologous Peptides.

Journal: Biomedicines

Published: November 21, 2025

PolyQ Expansion Controls Biomolecular Condensation and Aggregation of the N-Terminal Fragments of Ataxin-2.

PolyQ Expansion Controls Biomolecular Condensation and Aggregation of the N-Terminal Fragments of Ataxin-2.

Journal: International journal of molecular sciences

Published: October 03, 2025

A designer polyQ fusion protein modulates NF-κB signaling by sequestering P65/RelA into aggregates.

A designer polyQ fusion protein modulates NF-κB signaling by sequestering P65/RelA into aggregates.

Journal: Scientific reports

Published: April 25, 2025

The LSmAD Domain of Ataxin-2 Modulates the Structure and RNA Binding of Its Preceding LSm Domain.

The LSmAD Domain of Ataxin-2 Modulates the Structure and RNA Binding of Its Preceding LSm Domain.

Journal: Cells

Published: December 31, 2024

Co-Aggregation of TDP-43 with Other Pathogenic Proteins and Their Co-Pathologies in Neurodegenerative Diseases.

Co-Aggregation of TDP-43 with Other Pathogenic Proteins and Their Co-Pathologies in Neurodegenerative Diseases.

Journal: International journal of molecular sciences

Published: October 24, 2024

Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality.

Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality.

Journal: iScience

Published: July 03, 2024

PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6.

PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6.

Journal: The Journal of biological chemistry

Published: January 09, 2024

Ataxin-2 sequesters Raptor into aggregates and impairs cellular mTORC1 signaling.

Ataxin-2 sequesters Raptor into aggregates and impairs cellular mTORC1 signaling.

Journal: The FEBS journal

Published: August 02, 2023

Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis.

Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis.

Journal: Acta biochimica et biophysica Sinica

Published: May 12, 2023

PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation.

PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation.

Journal: The Journal of biological chemistry

Published: March 08, 2023

Sequestration of cellular native factors by biomolecular assemblies: Physiological or pathological?

Sequestration of cellular native factors by biomolecular assemblies: Physiological or pathological?

Journal: Biochimica et biophysica acta. Molecular cell research

Published: March 10, 2022

RNA-assisted sequestration of RNA-binding proteins by cytoplasmic inclusions of the C-terminal 35-kDa fragment of TDP-43.

RNA-assisted sequestration of RNA-binding proteins by cytoplasmic inclusions of the C-terminal 35-kDa fragment of TDP-43.

Journal: Journal of cell science

Published: September 15, 2021

Showing 1-12 of 42

Last Updated: 09/26/2026