Honghan Chen

State Key Laboratory Of Biotherapy
Chengdu, China

Last Updated: 09/26/2026

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Found 16 publications

Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.

Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.

Journal: Phytotherapy research : PTR
Published: August 11, 2025

Daytime-Restricted Feeding Alleviates D-Galactose-Induced Aging in Mice and Regulates the AMPK and mTORC1 Activities.

Daytime-Restricted Feeding Alleviates D-Galactose-Induced Aging in Mice and Regulates the AMPK and mTORC1 Activities.

Journal: Journal of cellular physiology
Published: September 01, 2024

Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation.

Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation.

Journal: Signal transduction and targeted therapy
Published: July 08, 2024

mTORC2: A neglected player in aging regulation.

mTORC2: A neglected player in aging regulation.

Journal: Journal of cellular physiology
Published: March 20, 2024

APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma.

APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma.

Journal: Oxidative medicine and cellular longevity
Published: August 06, 2022

Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.

Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.

Journal: Frontiers in pharmacology
Published: April 20, 2022

Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling.

Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling.

Journal: Biochemical pharmacology
Published: February 09, 2022

SeHed, a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect.

SeHed, a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect.

Journal: Signal transduction and targeted therapy
Published: October 25, 2021

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation.

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation.

Journal: Signal transduction and targeted therapy
Published: April 17, 2021

Microphthalmia-Associated Transcription Factor in Senescence and Age-Related Diseases.

Microphthalmia-Associated Transcription Factor in Senescence and Age-Related Diseases.

Journal: Gerontology
Published: October 15, 2020

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation.

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation.

Journal: Frontiers in immunology
Published: November 28, 2019

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress-induced senescence.

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress-induced senescence.

Journal: The Journal of biological chemistry
Published: August 23, 2019
Showing 1-12 of 16

Last Updated: 09/26/2026