Honghong Chen

London, ON, Canada

Last Updated: 09/26/2026

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Found 17 publications

Quantifying electrostatic control of docking and binding energetics in functional Cx36 gap junctions.

Quantifying electrostatic control of docking and binding energetics in functional Cx36 gap junctions.

Journal: Communications biology

Published: November 21, 2025

The rectification of heterotypic Cx46/Cx50 gap junction channels depends on intracellular magnesium.

The rectification of heterotypic Cx46/Cx50 gap junction channels depends on intracellular magnesium.

Journal: Biophysics reports

Published: March 24, 2024

Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels.

Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels.

Journal: The Biochemical journal

Published: January 18, 2024

Human Cx50 Isoleucine177 prevents heterotypic docking and formation of functional gap junction channels with Cx43.

Human Cx50 Isoleucine177 prevents heterotypic docking and formation of functional gap junction channels with Cx43.

Journal: American journal of physiology. Cell physiology

Published: December 25, 2023

Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43.

Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43.

Journal: The Biochemical journal

Published: March 28, 2023

Discovery of GJC1 (Cx45) as a New Gene Underlying Congenital Heart Disease and Arrhythmias.

Discovery of GJC1 (Cx45) as a New Gene Underlying Congenital Heart Disease and Arrhythmias.

Journal: Biology

Published: February 01, 2023

The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating.

The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating.

Journal: International journal of molecular sciences

Published: September 06, 2022

Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N-terminal domains.

Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N-terminal domains.

Journal: The Journal of physiology

Published: January 06, 2021

Connexin45 (GJC1) loss-of-function mutation contributes to familial atrial fibrillation and conduction disease.

Connexin45 (GJC1) loss-of-function mutation contributes to familial atrial fibrillation and conduction disease.

Journal: Heart rhythm

Published: October 31, 2020

The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions.

The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions.

Journal: Journal of molecular and cellular cardiology

Published: November 07, 2019

Heterotypic docking compatibility of human connexin37 with other vascular connexins.

Heterotypic docking compatibility of human connexin37 with other vascular connexins.

Journal: Journal of molecular and cellular cardiology

Published: October 12, 2018

Functional Characterization of Novel Atrial Fibrillation-Linked GJA5 (Cx40) Mutants.

Functional Characterization of Novel Atrial Fibrillation-Linked GJA5 (Cx40) Mutants.

Journal: International journal of molecular sciences

Published: February 23, 2018

Showing 1-12 of 17

Last Updated: 09/26/2026