Hongrui Lei

Key Laboratory Of Structure Based Drug Design And Discovery
Shenyang, 110016, China

Last Updated: 09/26/2026

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Found 29 publications

Structure-based identification of novel indole-fused polycyclic derivatives as potent acetylcholinesterase inhibitors.

Structure-based identification of novel indole-fused polycyclic derivatives as potent acetylcholinesterase inhibitors.

Journal: Bioorganic & medicinal chemistry
Published: June 20, 2026

Structure based identification of novel 4,5,6,7-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one derivatives as nonacidic ATX inhibitors with promising antifibrotic effects.

Structure based identification of novel 4,5,6,7-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one derivatives as nonacidic ATX inhibitors with promising antifibrotic effects.

Journal: European journal of medicinal chemistry
Published: April 29, 2026

Rational design and synthesis of 6-(piperazin-1-yl)imidazo[1,2-b]pyridazine derivatives as dual FXR/PPARδ agonists for treatment of pulmonary fibrosis.

Rational design and synthesis of 6-(piperazin-1-yl)imidazo[1,2-b]pyridazine derivatives as dual FXR/PPARδ agonists for treatment of pulmonary fibrosis.

Journal: European journal of medicinal chemistry
Published: June 17, 2025

Rational design and identification of potent imidazole-fused Autotaxin inhibitors for treatment of idiopathic pulmonary fibrosis.

Rational design and identification of potent imidazole-fused Autotaxin inhibitors for treatment of idiopathic pulmonary fibrosis.

Journal: European journal of medicinal chemistry
Published: June 06, 2025

Structural evolution progress of orally bioavailable selective estrogen receptor degraders.

Structural evolution progress of orally bioavailable selective estrogen receptor degraders.

Journal: Bioorganic & medicinal chemistry
Published: May 11, 2025

Research progress on covalent inhibitors targeting alkaline amino acids.

Research progress on covalent inhibitors targeting alkaline amino acids.

Journal: Bioorganic chemistry
Published: April 30, 2025

Development of Tricyclic 4,5-Dihydro-3H-pyrrolo[2,3-c]quinolin-4-ones as Potent Autotaxin Inhibitors for Pulmonary Fibrosis Treatment In Vivo.

Development of Tricyclic 4,5-Dihydro-3H-pyrrolo[2,3-c]quinolin-4-ones as Potent Autotaxin Inhibitors for Pulmonary Fibrosis Treatment In Vivo.

Journal: Journal of medicinal chemistry
Published: March 24, 2025

Development of potent indole-3-carboxamide autotaxin inhibitors with preferred lipophilicity for in vivo treatment of pulmonary fibrosis.

Development of potent indole-3-carboxamide autotaxin inhibitors with preferred lipophilicity for in vivo treatment of pulmonary fibrosis.

Journal: European journal of medicinal chemistry
Published: January 01, 2025

A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment.

A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment.

Journal: Journal of medicinal chemistry
Published: December 27, 2024

Discovery of Novel 4,5,6,7-Tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one Derivatives as Orally Efficacious ATX Allosteric Inhibitors for the Treatment of Pulmonary Fibrosis.

Discovery of Novel 4,5,6,7-Tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one Derivatives as Orally Efficacious ATX Allosteric Inhibitors for the Treatment of Pulmonary Fibrosis.

Journal: Journal of medicinal chemistry
Published: December 25, 2024

Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy.

Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy.

Journal: Journal of medicinal chemistry
Published: September 10, 2024

Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment.

Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment.

Journal: European journal of medicinal chemistry
Published: May 07, 2024
Showing 1-12 of 29

Last Updated: 09/26/2026