Honnappa Srinivas

Basel, BS 4002, Switzerland

Last Updated: 09/26/2026

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Found 16 publications

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement.

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement.

Journal: Journal of medicinal chemistry

Published: October 15, 2025

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Journal: Journal of medicinal chemistry

Published: February 17, 2025

Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.

Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.

Journal: Journal of medicinal chemistry

Published: November 22, 2024

Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.

Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.

Journal: Journal of medicinal chemistry

Published: March 13, 2024

ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.

ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.

Journal: Cell reports

Published: December 13, 2023

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

Journal: Journal of medicinal chemistry

Published: November 28, 2023

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

Journal: Journal of medicinal chemistry

Published: February 16, 2021

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.

Journal: Journal of medicinal chemistry

Published: July 16, 2020

Molecular Signature of the Immune Response to Yoga Therapy in Stress-related Chronic Disease Conditions: An Insight.

Molecular Signature of the Immune Response to Yoga Therapy in Stress-related Chronic Disease Conditions: An Insight.

Journal: International journal of yoga

Published: February 08, 2020

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Journal: Nature chemical biology

Published: January 17, 2020

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Journal: Nature chemical biology

Published: August 12, 2019

A small-molecule inhibitor of C5 complement protein.

A small-molecule inhibitor of C5 complement protein.

Journal: Nature chemical biology

Published: July 26, 2018

Showing 1-12 of 16

Last Updated: 09/26/2026