Howard J. Burt

Sheffield, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 13 publications

PBPK Modeling to Predict Clinical Drug-Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F-Hydroxypropylamide.

PBPK Modeling to Predict Clinical Drug-Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F-Hydroxypropylamide.

Journal: CPT: pharmacometrics & systems pharmacology

Published: January 26, 2025

Tipifarnib physiologically-based pharmacokinetic modeling to assess drug-drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients.

Tipifarnib physiologically-based pharmacokinetic modeling to assess drug-drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients.

Journal: CPT: pharmacometrics & systems pharmacology

Published: February 16, 2024

Development and application of a PBPK modeling strategy to support antimalarial drug development.

Development and application of a PBPK modeling strategy to support antimalarial drug development.

Journal: CPT: pharmacometrics & systems pharmacology

Published: February 27, 2023

Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency.

Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: December 22, 2020

Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction.

Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: November 06, 2019

Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.

Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.

Journal: Clinical pharmacology and therapeutics

Published: June 14, 2019

The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall.

The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: June 05, 2018

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.

Journal: Journal of pharmacokinetics and pharmacodynamics

Published: October 09, 2017

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: April 22, 2016

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: November 13, 2015

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-Mediated Clearances.

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-Mediated Clearances.

Journal: Journal of clinical pharmacology

Published: September 02, 2015

Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.

Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.

Journal: ACS medicinal chemistry letters

Published: May 25, 2013

Showing 1-12 of 13

Last Updated: 09/26/2026