Hsiao-fu Chang

Miaoli, TNQ 35053, Taiwan

Last Updated: 09/26/2026

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Found 9 publications

Structural Modification and Development of N-(1,2,3,4-Tetrahydro-3-isoquinolinylmethyl)benzamide, BPR1M492, as a Potent and Rapid-Onset Opioid Analgesic with Reduced Withdrawal Symptoms.

Structural Modification and Development of N-(1,2,3,4-Tetrahydro-3-isoquinolinylmethyl)benzamide, BPR1M492, as a Potent and Rapid-Onset Opioid Analgesic with Reduced Withdrawal Symptoms.

Journal: Journal of medicinal chemistry

Published: June 01, 2026

DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration.

DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration.

Journal: Journal of medicinal chemistry

Published: October 30, 2024

Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia.

Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia.

Journal: Cell chemical biology

Published: October 02, 2023

Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu-opioid receptor splice variants.

Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu-opioid receptor splice variants.

Journal: Pain

Published: February 11, 2020

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.

Journal: Neuropharmacology

Published: September 13, 2018

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice.

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice.

Journal: Scientific reports

Published: August 02, 2018

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.

Journal: Anesthesiology

Published: February 18, 2017

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.

Journal: European journal of medicinal chemistry

Published: July 15, 2016

The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice.

The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)

Published: May 21, 2013

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Last Updated: 09/26/2026