Hua Nie

Meizhou, 514031, China

Last Updated: 09/26/2026

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Found 35 publications

Discovery of a potent TDP1 inhibitor through machine learning-driven predictive modeling combined with structure-based virtual screening and experimental validation.

Discovery of a potent TDP1 inhibitor through machine learning-driven predictive modeling combined with structure-based virtual screening and experimental validation.

Journal: RSC advances

Published: June 09, 2026

Integrating machine learning and deep learning with multiple molecular fingerprints for topoisomerase I inhibitor screening and lead identification.

Integrating machine learning and deep learning with multiple molecular fingerprints for topoisomerase I inhibitor screening and lead identification.

Journal: Molecular diversity

Published: May 30, 2026

Design, Synthesis and Biological Evaluation of 6H-Benzimidazo[1',2':1,2]pyrido[3,4-b]indole Derivatives as TDP1 Inhibitors: Potent Synergistic Agents with Topotecan against Cervical Cancer.

Design, Synthesis and Biological Evaluation of 6H-Benzimidazo[1',2':1,2]pyrido[3,4-b]indole Derivatives as TDP1 Inhibitors: Potent Synergistic Agents with Topotecan against Cervical Cancer.

Journal: Journal of medicinal chemistry

Published: April 21, 2026

Targeted liposome entrapped iridium(III) complexes significantly increase antitumor activity in vitro and in vivo.

Targeted liposome entrapped iridium(III) complexes significantly increase antitumor activity in vitro and in vivo.

Journal: European journal of medicinal chemistry

Published: April 04, 2026

Targeted screening of phenylpropanoids from Dendropanax proteus for rheumatoid arthritis therapy and mechanistic insights.

Targeted screening of phenylpropanoids from Dendropanax proteus for rheumatoid arthritis therapy and mechanistic insights.

Journal: Bioorganic chemistry

Published: February 05, 2026

The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications.

The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications.

Journal: Biomolecules

Published: January 26, 2026

Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.

Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.

Journal: Frontiers in endocrinology

Published: January 20, 2026

Comprehensive S-acylation profiling of the porcine epididymis and exosomes reveals a role in cargo sorting and long-distance trafficking.

Comprehensive S-acylation profiling of the porcine epididymis and exosomes reveals a role in cargo sorting and long-distance trafficking.

Journal: Journal of proteomics

Published: January 03, 2026

A multidimensional clinical prediction model for early screening of recurrent spontaneous abortion: integrating coagulation, immune, and endocrine markers.

A multidimensional clinical prediction model for early screening of recurrent spontaneous abortion: integrating coagulation, immune, and endocrine markers.

Journal: Frontiers in immunology

Published: December 23, 2025

Establishing reference values and evaluating diagnostic utility of scrotal ultrasound for azoospermia subtypes: A cross-sectional study in Guangdong, China.

Establishing reference values and evaluating diagnostic utility of scrotal ultrasound for azoospermia subtypes: A cross-sectional study in Guangdong, China.

Journal: The ultrasound journal

Published: November 26, 2025

Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation.

Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation.

Journal: Journal of ethnopharmacology

Published: May 27, 2025

From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction.

From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction.

Journal: Frontiers in immunology

Published: March 24, 2025

Showing 1-12 of 35

Last Updated: 09/26/2026