Huajian Zhu

639 Longmian Avenue
Nanjing, 211198, China

Last Updated: 09/26/2026

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Found 36 publications

From Structure to Selectivity: Integrating CADD and AIDD in Rational Medicinal Chemistry Strategies for DYRK1A Inhibitor Discovery.

From Structure to Selectivity: Integrating CADD and AIDD in Rational Medicinal Chemistry Strategies for DYRK1A Inhibitor Discovery.

Journal: Journal of medicinal chemistry

Published: July 20, 2026

Beyond acrylamide: a structure-guided investigation of covalent warheads in the development of CDK7 inhibitors.

Beyond acrylamide: a structure-guided investigation of covalent warheads in the development of CDK7 inhibitors.

Journal: RSC medicinal chemistry

Published: February 04, 2026

Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance.

Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance.

Journal: Journal of medicinal chemistry

Published: December 05, 2025

Discovery of novel 20S proteasome activators for hypoxic cardiomyocyte protection via endoplasmic reticulum stress alleviation.

Discovery of novel 20S proteasome activators for hypoxic cardiomyocyte protection via endoplasmic reticulum stress alleviation.

Journal: Bioorganic & medicinal chemistry

Published: August 29, 2025

Development of Adamantane-based hydrophobic tags targeting anaplastic lymphoma kinase with enhanced antitumor activities.

Development of Adamantane-based hydrophobic tags targeting anaplastic lymphoma kinase with enhanced antitumor activities.

Journal: Bioorganic chemistry

Published: June 26, 2025

Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides.

Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides.

Journal: Bioorganic chemistry

Published: December 28, 2024

The Synthesis of Benzazepines via Sequential [3 + 2]-Annulation and [3,3]-Sigmatropic Rearrangement.

The Synthesis of Benzazepines via Sequential [3 + 2]-Annulation and [3,3]-Sigmatropic Rearrangement.

Journal: Organic letters

Published: November 22, 2024

In Vivo Self-Assembly of PROTACs by Bioorthogonal Chemistry for Precision Cancer Therapy.

In Vivo Self-Assembly of PROTACs by Bioorthogonal Chemistry for Precision Cancer Therapy.

Journal: Angewandte Chemie (International ed. in English)

Published: November 07, 2024

Synthesis of 1,1,3-Polyfunctionalized Cyclobutane Derivatives from the Reaction of Sulfur Ylides with Bicyclo[1.1.0]butanes.

Synthesis of 1,1,3-Polyfunctionalized Cyclobutane Derivatives from the Reaction of Sulfur Ylides with Bicyclo[1.1.0]butanes.

Journal: Organic letters

Published: August 29, 2024

Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection.

Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection.

Journal: Bioorganic & medicinal chemistry

Published: July 13, 2024

Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension.

Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension.

Journal: Journal of medicinal chemistry

Published: July 05, 2024

DiPTAC: A degradation platform via directly targeting proteasome.

DiPTAC: A degradation platform via directly targeting proteasome.

Journal: Acta pharmaceutica Sinica. B

Published: May 31, 2024

Showing 1-12 of 36

Last Updated: 09/26/2026