Hubert Hrebabecky

Prague, PR 16610, Czech Republic

Last Updated: 09/26/2026

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Found 21 publications

Compounds mimicking the Michaelis-Menten transition state of the phosphatidylinositol 4-kinase.

Compounds mimicking the Michaelis-Menten transition state of the phosphatidylinositol 4-kinase.

Journal: Bioorganic & medicinal chemistry

Published: February 20, 2026

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses.

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses.

Journal: Antiviral research

Published: May 20, 2020

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.

Journal: Journal of medicinal chemistry

Published: April 17, 2020

Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors.

Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors.

Journal: Journal of molecular recognition : JMR

Published: November 13, 2019

Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?

Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?

Journal: Bioorganic & medicinal chemistry letters

Published: September 29, 2019

Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes.

Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes.

Journal: Organic & biomolecular chemistry

Published: February 28, 2018

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.

Journal: Journal of medicinal chemistry

Published: December 23, 2016

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.

Journal: Antiviral research

Published: October 14, 2016

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors.

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: February 12, 2016

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction.

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction.

Journal: Free radical biology & medicine

Published: February 08, 2016

Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.

Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.

Journal: Organic & biomolecular chemistry

Published: August 05, 2015

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.

Journal: Journal of medicinal chemistry

Published: April 22, 2015

Showing 1-12 of 21

Last Updated: 09/26/2026