Hugh C. Sparks

Light Community
London, ENG SW72AZ, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

Application of dual-view oblique plane microscopy to small-molecule compound screening across 3D glioblastoma stem cell spheroids with single-cell resolution.

Application of dual-view oblique plane microscopy to small-molecule compound screening across 3D glioblastoma stem cell spheroids with single-cell resolution.

Journal: SLAS discovery : advancing life sciences R & D

Published: April 10, 2026

High content 3D imaging by dual-view oblique plane microscopy.

High content 3D imaging by dual-view oblique plane microscopy.

Journal: PNAS nexus

Published: July 28, 2025

Cleared tissue dual-view oblique plane microscopy.

Cleared tissue dual-view oblique plane microscopy.

Journal: Biomedical optics express

Published: July 03, 2025

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

Journal: Cancer discovery

Published: April 23, 2025

Geometric deep learning and multiple-instance learning for 3D cell-shape profiling.

Geometric deep learning and multiple-instance learning for 3D cell-shape profiling.

Journal: Cell systems

Published: February 23, 2024

Alignment and characterization of remote-refocusing systems.

Alignment and characterization of remote-refocusing systems.

Journal: Applied optics

Published: October 19, 2023

Environmentally dependent and independent control of 3D cell shape.

Environmentally dependent and independent control of 3D cell shape.

Journal: Cell reports

Published: January 30, 2023

Working at the interface of physics and biology: An early career researcher perspective.

Working at the interface of physics and biology: An early career researcher perspective.

Journal: iScience

Published: December 05, 2022

High-speed 2D light-sheet fluorescence microscopy enables quantification of spatially varying calcium dynamics in ventricular cardiomyocytes.

High-speed 2D light-sheet fluorescence microscopy enables quantification of spatially varying calcium dynamics in ventricular cardiomyocytes.

Journal: Frontiers in physiology

Published: October 25, 2022

Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture.

Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture.

Journal: Scientific reports

Published: September 19, 2022

Active mesh and neural network pipeline for cell aggregate segmentation.

Active mesh and neural network pipeline for cell aggregate segmentation.

Journal: Biophysical journal

Published: August 12, 2022

Video-rate remote refocusing through continuous oscillation of a membrane deformable mirror.

Video-rate remote refocusing through continuous oscillation of a membrane deformable mirror.

Journal: JPhys photonics

Published: March 28, 2021

Showing 1-12 of 21

Last Updated: 09/26/2026