Huihao M. Zhou

132 East Outer Ring Road
Guangzhou, 510006, China

Last Updated: 09/26/2026

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Found 90 publications

Crystallographic analysis of a putative FAD-dependent oxidoreductase identifies a potentially misfolded apo structure in a soluble monomeric state.

Crystallographic analysis of a putative FAD-dependent oxidoreductase identifies a potentially misfolded apo structure in a soluble monomeric state.

Journal: Journal of structural biology

Published: February 28, 2026

Substrate l-isoleucine facilitates the hyper inhibition of reveromycin A on human cytoplasmic isoleucyl-tRNA synthetase.

Substrate l-isoleucine facilitates the hyper inhibition of reveromycin A on human cytoplasmic isoleucyl-tRNA synthetase.

Journal: Archives of biochemistry and biophysics

Published: November 04, 2025

Discovery of a triple-site inhibitor targeting bacterial methionyl-tRNA synthetase through combined drug repurposing screening and generative AI-assisted optimization.

Discovery of a triple-site inhibitor targeting bacterial methionyl-tRNA synthetase through combined drug repurposing screening and generative AI-assisted optimization.

Journal: Nucleic acids research

Published: September 30, 2025

Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.

Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.

Journal: Journal of medicinal chemistry

Published: August 25, 2025

Structure-based design of tirabrutinib derivatives as inhibitors of bacterial tryptophanyl-tRNA synthetase.

Structure-based design of tirabrutinib derivatives as inhibitors of bacterial tryptophanyl-tRNA synthetase.

Journal: Bioorganic chemistry

Published: July 17, 2025

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid.

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid.

Journal: Plant biotechnology journal

Published: June 22, 2025

Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer.

Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: May 20, 2025

RORγ Hijacks HIF1α to Promote Peritoneal Metastasis of Gastric Cancer.

RORγ Hijacks HIF1α to Promote Peritoneal Metastasis of Gastric Cancer.

Journal: Cancer research

Published: April 18, 2025

Development of potent inhibitors targeting bacterial prolyl-tRNA synthetase through fluorine scanning-directed activity tuning.

Development of potent inhibitors targeting bacterial prolyl-tRNA synthetase through fluorine scanning-directed activity tuning.

Journal: European journal of medicinal chemistry

Published: February 20, 2025

UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.

UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.

Journal: Molecular cell

Published: December 03, 2024

Structure-guided inhibitor design targeting CntL provides the first chemical validation of the staphylopine metallophore system in bacterial metal acquisition.

Structure-guided inhibitor design targeting CntL provides the first chemical validation of the staphylopine metallophore system in bacterial metal acquisition.

Journal: European journal of medicinal chemistry

Published: September 28, 2024

Discovery of Novel Neo-Clerodane Derivatives as Potent Dual-Functional Antiosteoporosis Agents through Targeting Peroxisome Proliferator-Activated Receptor-γ.

Discovery of Novel Neo-Clerodane Derivatives as Potent Dual-Functional Antiosteoporosis Agents through Targeting Peroxisome Proliferator-Activated Receptor-γ.

Journal: Journal of medicinal chemistry

Published: August 26, 2024

Showing 1-12 of 90

Last Updated: 09/26/2026