Hye K. Sung

Toronto, ON M3J1P3, Canada

Last Updated: 09/26/2026

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Found 31 publications

ALY688 confers cardioprotection through macrophage TGFβ-mediated Treg/Th17 dependent multi-organ responses.

ALY688 confers cardioprotection through macrophage TGFβ-mediated Treg/Th17 dependent multi-organ responses.

Journal: Pharmacological research
Published: May 12, 2026

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury.

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury.

Journal: Advanced healthcare materials
Published: January 07, 2026

Iron and lipid dysregulation as key determinants of ferroptosis in cardiometabolic disease.

Iron and lipid dysregulation as key determinants of ferroptosis in cardiometabolic disease.

Journal: Progress in lipid research
Published: December 07, 2025

Systemic Metabolomic Remodeling in Pressure Overload-Induced Heart Failure Indicates Modulation of a Gut-Liver-Heart Axis by the Adiponectin Receptor Agonist ALY688.

Systemic Metabolomic Remodeling in Pressure Overload-Induced Heart Failure Indicates Modulation of a Gut-Liver-Heart Axis by the Adiponectin Receptor Agonist ALY688.

Journal: Metabolites
Published: December 04, 2025

ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.

ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.

Journal: Journal of extracellular vesicles
Published: November 07, 2025

Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.

Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.

Journal: MedComm
Published: August 14, 2025

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro-Oxidative and Pro-Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction.

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro-Oxidative and Pro-Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction.

Journal: Journal of extracellular vesicles
Published: July 08, 2025

ALY688 Attenuates Iron-Induced ER Stress and Insulin Resistance via Activation of ER-Phagy.

ALY688 Attenuates Iron-Induced ER Stress and Insulin Resistance via Activation of ER-Phagy.

Journal: Diabetes
Published: April 27, 2025

ω-6 PUFA-enriched membrane phospholipid composition of cardiomyocytes increases the susceptibility to iron-induced ferroptosis and inflammation.

ω-6 PUFA-enriched membrane phospholipid composition of cardiomyocytes increases the susceptibility to iron-induced ferroptosis and inflammation.

Journal: Apoptosis : an international journal on programmed cell death
Published: April 17, 2025

The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan.

The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan.

Journal: Ageing research reviews
Published: March 24, 2025

Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart.

Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart.

Journal: Autophagy reports
Published: March 21, 2024

Salubrinal promotes phospho-eIF2α-dependent activation of UPR leading to autophagy-mediated attenuation of iron-induced insulin resistance.

Salubrinal promotes phospho-eIF2α-dependent activation of UPR leading to autophagy-mediated attenuation of iron-induced insulin resistance.

Journal: Molecular metabolism
Published: December 08, 2023
Showing 1-12 of 31

Last Updated: 09/26/2026