Ilaria Fregno
Bellinzona, TI, Switzerland
Last Updated: 09/26/2026
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Found 16 publications
CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes.
Journal: Autophagy reports
Published: November 03, 2025
Allosteric Modulation of GCase Enhances Lysosomal Activity and Reduces ER Stress in GCase-Related Disorders.
Journal: International journal of molecular sciences
Published: April 04, 2025
A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models.
Journal: Scientific reports
Published: October 26, 2024
ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction.
Journal: EMBO reports
Published: March 01, 2024
Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors.
Journal: PloS one
Published: May 31, 2023
N-glycan processing selects ERAD-resistant misfolded proteins for ER-to-lysosome-associated degradation.
Journal: The EMBO journal
Published: November 05, 2020
Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways.
Journal: Critical reviews in biochemistry and molecular biology
Published: May 16, 2019
Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice.
Journal: PLoS genetics
Published: September 24, 2018
A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.
Journal: The EMBO journal
Published: May 17, 2018
Eat it right: ER-phagy and recovER-phagy.
Journal: Biochemical Society transactions
Published: April 11, 2018
Last Updated: 09/26/2026