Ing-jun Chen
Kaohsiung, KHQ 80708, Taiwan
Last Updated: 09/26/2026
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Found 21 publications
KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes.
Journal: Molecules (Basel, Switzerland)
Published: August 30, 2018
Restoration of uridine 5'-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells.
Journal: The Kaohsiung journal of medical sciences
Published: July 26, 2016
Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice.
Journal: International journal of molecular sciences
Published: June 26, 2016
KMUP-1 attenuates high glucose and transforming growth factor-β1-induced pro-fibrotic proteins in mesangial cells.
Journal: Molecular medicine reports
Published: December 14, 2015
Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase.
Journal: Pediatric pulmonology
Published: November 09, 2015
Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia-induced apoptosis in endothelial progenitor cells.
Journal: The Journal of pharmacy and pharmacology
Published: November 01, 2015
Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization.
Journal: The Kaohsiung journal of medical sciences
Published: October 20, 2015
KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways.
Journal: Molecules (Basel, Switzerland)
Published: March 19, 2015
The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K⁺-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries.
Journal: International journal of biological sciences
Published: November 20, 2014
KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.
Journal: Journal of cellular physiology
Published: May 26, 2014
Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery.
Journal: The Kaohsiung journal of medical sciences
Published: May 22, 2014
Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
Journal: The Kaohsiung journal of medical sciences
Published: November 07, 2013
Last Updated: 09/26/2026