Iris K. Wong

State Key Laboratory Of Chemical Biology And Drug Discovery
Sar, China

Last Updated: 09/26/2026

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Found 29 publications

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety.

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety.

Journal: RSC medicinal chemistry

Published: June 12, 2024

Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04.

Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04.

Journal: Journal of medicinal chemistry

Published: April 25, 2023

In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31.

In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31.

Journal: International journal of molecular sciences

Published: January 09, 2023

Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.

Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.

Journal: International journal of molecular sciences

Published: October 14, 2022

Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).

Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).

Journal: International journal of molecular sciences

Published: September 20, 2022

Localization of Epigenetic Markers in Leishmania Chromatin.

Localization of Epigenetic Markers in Leishmania Chromatin.

Journal: Pathogens (Basel, Switzerland)

Published: August 02, 2022

Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).

Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).

Journal: Journal of medicinal chemistry

Published: October 04, 2021

Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.

Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.

Journal: European journal of medicinal chemistry

Published: April 23, 2021

Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis.

Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis.

Journal: Antimicrobial agents and chemotherapy

Published: March 09, 2021

SALL4 promotes tumor progression in breast cancer by targeting EMT.

SALL4 promotes tumor progression in breast cancer by targeting EMT.

Journal: Molecular carcinogenesis

Published: April 15, 2020

Disruption of SND1-MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo.

Disruption of SND1-MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo.

Journal: Molecular cancer therapeutics

Published: February 24, 2020

Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Journal: Journal of medicinal chemistry

Published: August 30, 2019

Showing 1-12 of 29

Last Updated: 09/26/2026