Isabel Y. Pappworth

Newcastle Upon Tyne, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 14 publications

Properdin deficiency or anti-properdin treatment ameliorates disease in the C3 gain-of-function mouse model of atypical haemolytic uraemic syndrome.

Properdin deficiency or anti-properdin treatment ameliorates disease in the C3 gain-of-function mouse model of atypical haemolytic uraemic syndrome.

Journal: Frontiers in immunology
Published: March 11, 2026

Biallelic pathogenic variants in EXOSC3 mediate renal thrombotic microangiopathy of the kidney.

Biallelic pathogenic variants in EXOSC3 mediate renal thrombotic microangiopathy of the kidney.

Journal: Kidney international
Published: February 10, 2026

The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.

The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.

Journal: Kidney international
Published: December 05, 2023

Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy.

Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy.

Journal: Cancers
Published: July 26, 2022

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice.

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice.

Journal: Frontiers in immunology
Published: August 03, 2021

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.

Journal: Frontiers in immunology
Published: March 15, 2021

C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.

C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.

Journal: Clinical journal of the American Society of Nephrology : CJASN
Published: January 09, 2021

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.

Journal: The Journal of clinical investigation
Published: December 15, 2017

A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.

A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.

Journal: Immunobiology
Published: August 07, 2017

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

Journal: Immunobiology
Published: September 10, 2015

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy.

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy.

Journal: Kidney international
Published: March 06, 2015

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

Journal: Molecular immunology
Published: July 13, 2014
Showing 1-12 of 14

Last Updated: 09/26/2026