Itsuro Shimada
Tsukuba, 3058585, Japan
Last Updated: 09/26/2026
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Found 8 publications
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Journal: Bioorganic & medicinal chemistry
Published: November 23, 2023
Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors.
Journal: Bioorganic & medicinal chemistry
Published: January 27, 2019
Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor.
Journal: Chemical & pharmaceutical bulletin
Published: March 02, 2018
Characterization and Thermodynamic Stability of Polymorphs of Di(arylamino) Aryl Compound ASP3026.
Journal: Chemical & pharmaceutical bulletin
Published: June 02, 2015
The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice.
Journal: Molecular cancer therapeutics
Published: January 15, 2014
Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors.
Journal: Journal of medicinal chemistry
Published: July 11, 2013
Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors.
Journal: Bioorganic & medicinal chemistry
Published: October 12, 2011
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Last Updated: 09/26/2026