Ivo Frydrych

Olomouc, 77146, Czech Republic

Last Updated: 09/26/2026

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Found 26 publications

Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells.

Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells.

Journal: European journal of medicinal chemistry

Published: August 29, 2025

Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors.

Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors.

Journal: The FEBS journal

Published: January 22, 2025

Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis.

Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis.

Journal: European journal of medicinal chemistry

Published: November 01, 2024

The kinetics of uracil-N-glycosylase distribution inside replication foci.

The kinetics of uracil-N-glycosylase distribution inside replication foci.

Journal: Scientific reports

Published: October 14, 2024

Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1.

Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1.

Journal: The Journal of biological chemistry

Published: September 21, 2024

Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis.

Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis.

Journal: Frontiers in immunology

Published: September 04, 2024

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action.

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action.

Journal: European journal of medicinal chemistry

Published: March 01, 2024

Basic Methods of Cell Cycle Analysis.

Basic Methods of Cell Cycle Analysis.

Journal: International journal of molecular sciences

Published: January 11, 2023

Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes.

Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes.

Journal: European journal of medicinal chemistry

Published: September 21, 2022

Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.

Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.

Journal: European journal of medicinal chemistry

Published: August 15, 2022

The epigenetic impact of suberohydroxamic acid and 5‑Aza‑2'‑deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL‑6 expression.

The epigenetic impact of suberohydroxamic acid and 5‑Aza‑2'‑deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL‑6 expression.

Journal: Molecular medicine reports

Published: July 15, 2021

Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.

Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.

Journal: European journal of medicinal chemistry

Published: June 07, 2021

Showing 1-12 of 26

Last Updated: 09/26/2026