Jack P. Uetrecht

144 College Street
Toronto, ON M5S3M2, Canada

Last Updated: 09/26/2026

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Found 89 publications

Hepatic Responses as Potential Biomarkers of Idiosyncratic Drug Reaction Risk.

Hepatic Responses as Potential Biomarkers of Idiosyncratic Drug Reaction Risk.

Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: July 29, 2026

Relevance of Reactive Metabolites and Covalent Binding to Drug Candidate Selection.

Relevance of Reactive Metabolites and Covalent Binding to Drug Candidate Selection.

Journal: Drug metabolism reviews
Published: January 27, 2026

DILI prediction in drug development: present and future.

DILI prediction in drug development: present and future.

Journal: Expert opinion on drug metabolism & toxicology
Published: April 20, 2025

TAK-994 mechanistic investigation into drug-induced liver injury.

TAK-994 mechanistic investigation into drug-induced liver injury.

Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: January 09, 2025

Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for Alzheimer's disease.

Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for Alzheimer's disease.

Journal: Nanotoxicology
Published: June 07, 2024

The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapine.

The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapine.

Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: May 20, 2024

The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury.

The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury.

Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: April 18, 2024

The development and characterization of a CRISPR/Cas9-mediated PD-1 functional knockout rat as a tool to study idiosyncratic drug reactions.

The development and characterization of a CRISPR/Cas9-mediated PD-1 functional knockout rat as a tool to study idiosyncratic drug reactions.

Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: January 17, 2024

Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash.

Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash.

Journal: Chemical research in toxicology
Published: November 03, 2023

Involvement of Extracellular Vesicles in the Proinflammatory Response to Clozapine: Implications for Clozapine-Induced Agranulocytosis.

Involvement of Extracellular Vesicles in the Proinflammatory Response to Clozapine: Implications for Clozapine-Induced Agranulocytosis.

Journal: The Journal of pharmacology and experimental therapeutics
Published: October 11, 2023

The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis.

The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis.

Journal: International journal of molecular sciences
Published: December 08, 2022

Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective.

Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective.

Journal: Chemical research in toxicology
Published: June 10, 2022
Showing 1-12 of 89

Last Updated: 09/26/2026