Jacob A. Mcphail

Suite 117-1537 Hillside Ave
Victoria, BC V8T2C1, Canada

Last Updated: 09/26/2026

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Found 18 publications

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Journal: Nature

Published: November 29, 2025

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency.

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency.

Journal: Nature communications

Published: March 07, 2025

Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy.

Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy.

Journal: Translational psychiatry

Published: November 08, 2024

Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms.

Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: May 30, 2024

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.

Journal: Science advances

Published: November 15, 2023

Molecular mechanisms of PI4K regulation and their involvement in viral replication.

Molecular mechanisms of PI4K regulation and their involvement in viral replication.

Journal: Traffic (Copenhagen, Denmark)

Published: January 06, 2022

Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.

Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.

Journal: ACS infectious diseases

Published: September 23, 2020

Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.

Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.

Journal: Advances in experimental medicine and biology

Published: September 07, 2020

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.

Journal: Journal of medicinal chemistry

Published: June 28, 2019

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.

Journal: EMBO reports

Published: May 09, 2019

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Journal: Antimicrobial agents and chemotherapy

Published: October 26, 2018

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Journal: Nature communications

Published: June 04, 2018

Showing 1-12 of 18

Last Updated: 09/26/2026