Jacob Neeves

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 10 publications

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS.

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS.

Journal: Science advances
Published: August 22, 2025

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition.

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition.

Journal: Neuron
Published: October 19, 2022

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.

Journal: Nature communications
Published: September 09, 2022

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis.

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis.

Journal: Genome research
Published: May 03, 2022

Reactive astrocytes in ALS display diminished intron retention.

Reactive astrocytes in ALS display diminished intron retention.

Journal: Nucleic acids research
Published: November 18, 2020

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.

Journal: Brain : a journal of neurology
Published: July 23, 2020

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.

Journal: Brain : a journal of neurology
Published: April 09, 2019

TDP-43 mutations increase HNRNP A1-7B through gain of splicing function.

TDP-43 mutations increase HNRNP A1-7B through gain of splicing function.

Journal: Brain : a journal of neurology
Published: October 27, 2018

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.

Journal: Acta neuropathologica
Published: May 22, 2018

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury.

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury.

Journal: PloS one
Published: June 27, 2017
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Last Updated: 09/26/2026