Jacob Piehler
Osnabrueck, NI, Germany
Last Updated: 09/26/2026
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Found 120 publications
Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.
Journal: Science advances
Published: July 10, 2026
Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: April 28, 2026
A Modular Toolkit for Nanoscale Interrogation of Multiprotein Assemblies Inside Living Cells.
Journal: ACS nano
Published: March 06, 2026
TORC1-dependent sorting of PI(3,5)P2 is required for vacuole membrane remodeling and signaling endosome formation.
Journal: Molecular biology of the cell
Published: November 05, 2025
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.
Journal: Science advances
Published: July 04, 2025
Design of facilitated dissociation enables control over cytokine signaling duration.
Journal: bioRxiv : the preprint server for biology
Published: November 28, 2024
Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy.
Journal: Science signaling
Published: November 19, 2024
Design of facilitated dissociation enables timing of cytokine signalling.
Journal: Nature
Published: October 24, 2024
Tuning of G-CSFR signaling by de novo-designed agonists.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: May 13, 2024
A strategy to design protein-based antagonists against type I cytokine receptors.
Journal: PLoS biology
Published: January 16, 2024
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Journal: Nature communications
Published: November 03, 2023
Last Updated: 09/26/2026