Jacqueline L. Fok

Oncology R&D, AstraZeneca
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 8 publications

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

Journal: PLoS biology

Published: July 12, 2021

Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development.

Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development.

Journal: Molecular cancer therapeutics

Published: June 19, 2020

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.

Journal: Nature communications

Published: March 28, 2019

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

Journal: Science advances

Published: January 31, 2018

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: June 20, 2017

Heat shock proteins in multiple myeloma.

Heat shock proteins in multiple myeloma.

Journal: Oncotarget

Published: March 29, 2014

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

Journal: PloS one

Published: January 20, 2014

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress.

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress.

Journal: Cancer letters

Published: May 24, 2013

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Last Updated: 09/26/2026